Publication in Chemico-Biological Interactions

Gold(I) N-heterocyclic carbene complexes show strong proapoptotic, antioxidant and anti-inflammatory effects in A2780 and endothelial cells

Authors: Zdeněk Trávníček, Ján Vančo, Michal Čajan, Tomáš Malina, Zdeněk Dvořák, René Lenobel, Barbora Beláková, Johannes A. Schmid

Full-text: https://doi.org/10.1016/j.cbi.2025.111381

 

Highlights

– Au(I)-NHC complexes (1–8) with 7-azaindole derivatives were prepared and characterised.

– Showed significant in vitro cytotoxicity on ovarian A2780 and A2780R cancer cells.

– Showed proapoptotic effect at A2780 cells via damaging mitochondria

– Complexes 1 and 7 showed remarkable anti-inflammatory effects by inhibiting NF-kB.

– The proteomic analysis revealed molecular effects of 1 and 7 on the A2780 proteome.