Publication in Chemico-Biological Interactions
Gold(I) N-heterocyclic carbene complexes show strong proapoptotic, antioxidant and anti-inflammatory effects in A2780 and endothelial cells
Authors: Zdeněk Trávníček, Ján Vančo, Michal Čajan, Tomáš Malina, Zdeněk Dvořák, René Lenobel, Barbora Beláková, Johannes A. Schmid
Full-text: https://doi.org/10.1016/j.cbi.2025.111381
Highlights
– Au(I)-NHC complexes (1–8) with 7-azaindole derivatives were prepared and characterised.
– Showed significant in vitro cytotoxicity on ovarian A2780 and A2780R cancer cells.
– Showed proapoptotic effect at A2780 cells via damaging mitochondria
– Complexes 1 and 7 showed remarkable anti-inflammatory effects by inhibiting NF-kB.
– The proteomic analysis revealed molecular effects of 1 and 7 on the A2780 proteome.
6/3/2025