Qualification
| 1998-2003 | M.S. in Biochemistry, Department of Biochemistry and Microbiology, Faculty of Food and Biochemical Technology, Institute of Chemical Technology in Prague, Czech Republic Thesis: „Immunochemical detection of endosulfan“ |
| 2003-2007 | Ph.D. with co-supervision (cotutelle de these) at Institute of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic and Detoxication et Physiopathologie Hepatique, Institute National de la Sante Et de la Recherche Medicale, INSERM U632, CNRS, Montpellier, France (group of Dr.Maurel) Thesis: „Effects of microtubule-interfering agents on aryl hydrocarbon receptor signalling“ |
| 2006-2008 | Assistent professor, Institute of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic |
| 2008-2011 | Assistent professor, Department of Cell Biology and Genetics, Palacky University, Olomouc, Czech Republic |
| Since 2011 | Associate professor, Department of Cell Biology and Genetics, Palacky University, Olomouc, Czech Republic |
Research interests
- Regulation of biotransformation enzymes expression
- Drug-drug interactions
Publication activity
- Počet publikací (WoS): 47
- Počet citací (WoS): 558
- H-index: 16
Foreign research stays
| 2005, 2006 | Detoxication et Physiopathologie Hepatique, Institute National de la Sante Et de la Recherche Medicale, INSERM U632, CNRS, Montpellier, France (group of Dr.Maurel) |
| 2009 | Hungarian Academy of Sciences, Chemical Research Center, Budapest, Hungary – (group of Dr. Katalin Monostory) (3 weeks) |
| 2014 | UniversitätsKlinikum Heidelberg, Clinical Pharmacology and Pharmacoepidemiology, Heidelberg, Germany (group of Prof.Johanna Weiss) (1 month) |
Further activities
- Principal investigator of GACR project (305/08/P089) – 2008-2010
- Co-investigator of GACR project (P303/12/0472) – 2012-2016
Selected publications
Dvorak, Srovnalova, Svecarova, Vrzal: The effect of anthocyans on the expression of selected phase II xenobiotic-metabolizing enzymes in primary cultures of human hepatocytes. Food Funct. 2014, 5(9): 2145-51. (IF2013 = 2,907)
Vrzal et al: Khellin and Visnagin Differentially Modulate AHR Signaling and Downstream CYP1A Activity in Human Liver Cells. PLOS ONE. 2013, 8(9). (IF2013 = 3,73)